HLA-B*83

HLA-B*83 is a specific allele group of the human leukocyte antigen (HLA) B gene. The HLA system is a complex genetic system that plays a crucial role in the immune response of humans. HLA-B*83 is one of the rarest HLA-B alleles and has been identified in a limited number of individuals worldwide.

Function

The HLA-B gene is part of the major histocompatibility complex (MHC) class I molecules, which are expressed on the surface of almost all nucleated cells. The primary function of these molecules is to present peptide antigens to cytotoxic T cells. This antigen presentation is a critical step in the immune response, leading to the destruction of infected or malignant cells.

HLA-B*83, like other HLA-B alleles, codes for a protein that binds to specific peptide antigens and presents them on the cell surface. The specific antigens recognized by HLA-B*83 are not yet fully understood due to the rarity of this allele.

Distribution and Frequency

HLA-B*83 is one of the least common HLA-B alleles. It has been identified in a limited number of individuals, and its frequency in the general population is not well established. Further research is needed to determine the geographic and ethnic distribution of HLA-B*83.

Clinical Significance

The clinical significance of HLA-B*83 is currently unknown. However, other HLA-B alleles have been associated with susceptibility or resistance to certain diseases, including infectious diseases, autoimmune disorders, and cancers. Further research is needed to determine whether HLA-B*83 has any clinical implications.

Research

Due to its rarity, HLA-B*83 has been the subject of limited research. Future studies are needed to determine its antigenic specificity, its distribution in different populations, and its potential clinical significance.