HLA-B12

From WikiMD's Wellness Encyclopedia

HLA-B12 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that are crucial for the function of the immune system. HLA-B12 is part of the HLA-B locus, which is a highly polymorphic gene family located on the short arm of chromosome 6.

Function[edit | edit source]

HLA-B12 is involved in the presentation of antigens to the T cells of the immune system. This is a crucial step in the immune response, as it allows the immune system to recognize and respond to foreign substances. The HLA-B12 molecule is a cell surface protein that binds to antigens and presents them to T cells.

Genetics[edit | edit source]

The HLA-B12 serotype is determined by the HLA-B*12 allele group. This group contains many different alleles, each of which can produce a slightly different version of the HLA-B12 molecule. The diversity of these alleles is thought to be a result of evolutionary pressure from pathogens.

Clinical significance[edit | edit source]

HLA-B12 has been associated with a number of diseases, including rheumatoid arthritis, ankylosing spondylitis, and psoriasis. It is thought that certain HLA-B12 alleles may increase susceptibility to these diseases by altering the immune response.

See also[edit | edit source]

References[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD