HLA-B12

HLA-B12 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that are crucial for the function of the immune system. HLA-B12 is part of the HLA-B locus, which is a highly polymorphic gene family located on the short arm of chromosome 6.

Function

HLA-B12 is involved in the presentation of antigens to the T cells of the immune system. This is a crucial step in the immune response, as it allows the immune system to recognize and respond to foreign substances. The HLA-B12 molecule is a cell surface protein that binds to antigens and presents them to T cells.

Genetics

The HLA-B12 serotype is determined by the HLA-B*12 allele group. This group contains many different alleles, each of which can produce a slightly different version of the HLA-B12 molecule. The diversity of these alleles is thought to be a result of evolutionary pressure from pathogens.

Clinical significance

HLA-B12 has been associated with a number of diseases, including rheumatoid arthritis, ankylosing spondylitis, and psoriasis. It is thought that certain HLA-B12 alleles may increase susceptibility to these diseases by altering the immune response.

See also

• HLA-B
• Human leukocyte antigen
• Immune system
• Antigen presentation

References

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian