HLA-B14

HLA-B14 is a human leukocyte antigen serotype within the HLA-B serotype group. The serotype is determined by the antibody recognition of antigen B14. This group is a part of the larger HLA system, which is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell-surface proteins are responsible for the regulation of the immune system in humans.

Function

HLA-B14 is a HLA class I molecule, like all B serotypes. Class I molecules, including HLA-B14, play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells.

Alleles

HLA-B14 is an allele group rather than a single allele, with multiple subtypes. Some of these subtypes are B*14:01, B*14:02, and B*14:03. Each subtype can have different interactions with diseases and drugs.

Disease Associations

HLA-B14 has been associated with various diseases. For example, it has been linked to a slower progression of HIV infection. It is also associated with an increased risk of developing rheumatoid arthritis.

See Also

• HLA-B
• Human leukocyte antigen
• Major histocompatibility complex
• HLA class I