HLA-B15

HLA-B15 is a human leukocyte antigen serotype within the HLA-B serotype group. The serotype is determined by the antibody recognition of antigen B15. This group is a part of the larger HLA system, which is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell-surface proteins are responsible for the regulation of the immune system in humans.

Function

HLA-B15 is a protein that in humans is encoded by the HLA-B gene. The protein encoded by this gene is a member of the MHC class I molecules, which are proteins that display foreign antigens to the immune system. This can trigger an immune response, leading to the destruction of the infected cell.

Clinical significance

HLA-B15 has been associated with a number of diseases, including celiac disease, rheumatoid arthritis, and psoriasis. It is also associated with a higher risk of graft-versus-host disease following organ transplantation.

See also

• HLA-B
• Human leukocyte antigen
• Major histocompatibility complex
• Antigen presentation

References

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