HLA-B5

HLA-B5 is a human leukocyte antigen serotype within the HLA-B serotype group. The serotype is determined by the antibody recognition of antigen B5. This group is a part of the larger HLA system, which is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. These cell-surface proteins are responsible for the regulation of the immune system.

Function

HLA-B5 is a cell-surface protein that plays a crucial role in the immune system. It is involved in the presentation of foreign peptides to the immune system. This process is essential for the immune system to recognize and respond to foreign substances, such as pathogens and cancer cells.

Clinical significance

HLA-B5 has been associated with several diseases, including Behçet's disease, ankylosing spondylitis, and certain types of cancer. The presence of this antigen can influence the course of these diseases and the response to treatment.

Genetics

The HLA-B5 antigen is encoded by the HLA-B*5 gene, which is located on the short arm of chromosome 6. This gene is highly polymorphic, meaning that there are many different versions of the gene in the population. The specific version of the gene that a person has can influence their susceptibility to certain diseases.

See also

• HLA-B
• Human leukocyte antigen
• Major histocompatibility complex
• Behçet's disease
• Ankylosing spondylitis