HLA-B60

HLA-B60 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that encode for proteins on the surface of cells that are responsible for regulation of the immune system in humans. HLA-B60 is part of the HLA-B serotype group, which is located on the short arm of chromosome 6.

Function

HLA-B60 is involved in the presentation of peptides (small proteins) from inside the cell to the immune system. This is a crucial part of the immune response, as it allows the immune system to recognize and respond to pathogens and other foreign substances.

Association with Disease

HLA-B60 has been associated with a number of diseases, including rheumatoid arthritis, ankylosing spondylitis, and psoriasis. However, the exact role of HLA-B60 in these diseases is not fully understood and is the subject of ongoing research.

Genetic Diversity

Like many HLA genes, HLA-B60 is highly polymorphic, meaning that there are many different versions (or alleles) of the gene in the human population. This genetic diversity is thought to be a result of evolutionary pressure from pathogens, as it allows the immune system to recognize a wide range of foreign substances.

See Also

• HLA-B
• Human leukocyte antigen
• Immune system
• Rheumatoid arthritis
• Ankylosing spondylitis
• Psoriasis