HLA-B70

HLA-B70 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that are crucial for the function of the immune system. HLA-B70 is part of the HLA-B locus, which is a subcategory of the larger HLA system.

Function

HLA-B70 is involved in the presentation of antigens to the immune system. This is a crucial step in the immune response, as it allows the immune system to recognize and respond to foreign substances. The HLA-B70 molecule presents antigens to T cells, which then initiate an immune response.

Genetics

HLA-B70 is encoded by the HLA-B*70 allele group. This group contains two known alleles: HLA-B*7001 and HLA-B*7002. These alleles are relatively rare in the global population, with the highest frequencies found in certain ethnic groups in Africa and Asia.

Clinical significance

HLA-B70 has been associated with a number of diseases, including HIV infection and certain types of cancer. Studies have shown that individuals with the HLA-B*7002 allele may have a slower progression of HIV infection. However, more research is needed to fully understand the role of HLA-B70 in disease.

See also

• HLA-B
• Human leukocyte antigen
• Antigen presentation
• T cell