HLA-B76

From WikiMD's Wellness Encyclopedia

HLA-B76 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that are crucial for the function of the immune system. HLA-B76 is part of the HLA-B serotype group, which is one of the three major types of HLA class I molecules.

Function[edit | edit source]

HLA-B76, like other HLA class I molecules, plays a vital role in the immune system's defense against pathogens. It presents peptides derived from the interior of the cell to T cells, which are a type of white blood cell. If the T cells recognize the peptides as foreign (for example, if they are derived from a virus or bacteria), they will trigger an immune response.

Genetics[edit | edit source]

HLA-B76 is encoded by the HLA-B*76 allele group. This group contains many different alleles, each of which can produce a slightly different version of the HLA-B76 molecule. The exact number of HLA-B*76 alleles is not known, as new ones are still being discovered.

Clinical significance[edit | edit source]

Certain HLA-B*76 alleles have been associated with an increased risk of certain diseases. For example, HLA-B*7602 has been linked to a higher risk of ankylosing spondylitis, a type of arthritis that affects the spine.

See also[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD