HLA-B78

HLA-B78 is a human leukocyte antigen (HLA) serotype. The HLA system is a group of genes that are important in the immune system's ability to recognize and respond to foreign substances. HLA-B78 is part of the HLA-B locus, which is one of three major loci in the HLA system.

Function

HLA-B78 is involved in the presentation of peptides (small proteins) to the immune system. This is a crucial step in the immune response, as it allows the immune system to recognize and respond to foreign substances.

The HLA-B78 molecule is a cell surface protein that binds to peptides derived from the breakdown of proteins within the cell. These peptides are then presented to T cells, a type of white blood cell that plays a key role in the immune response.

Association with disease

Certain HLA types, including HLA-B78, have been associated with an increased risk of certain diseases. For example, HLA-B78 has been linked to an increased risk of ankylosing spondylitis, a type of arthritis that affects the spine.

However, the relationship between HLA types and disease risk is complex and not fully understood. It is likely that other genetic and environmental factors also play a role.

See also

• Human leukocyte antigen
• Ankylosing spondylitis
• T cells