HLA-DQB2
HLA-DQB2 is a gene that provides instructions for making a protein that plays a critical role in the immune system. The HLA-DQB2 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.
Structure[edit | edit source]
The HLA-DQB2 gene is located on the short (p) arm of chromosome 6 at position 21. The gene spans approximately 6 kilobases and comprises six exons. The protein encoded by this gene is a beta chain of the major histocompatibility complex (MHC) class II molecules, which are expressed in antigen-presenting cells (APCs).
Function[edit | edit source]
The protein produced by the HLA-DQB2 gene plays a vital role in the immune system's defense against foreign substances. It does this by binding to peptides derived from these substances and presenting them on the cell surface for recognition by the appropriate T-cells. This process is crucial for the immune system's ability to fight off infections and diseases.
Clinical significance[edit | edit source]
Alterations in the HLA-DQB2 gene have been associated with various autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and celiac disease. Further research is needed to fully understand the role of HLA-DQB2 in these and other conditions.
See also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD