HLA-DQB2

HLA-DQB2 is a gene that provides instructions for making a protein that plays a critical role in the immune system. The HLA-DQB2 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

Structure

The HLA-DQB2 gene is located on the short (p) arm of chromosome 6 at position 21. The gene spans approximately 6 kilobases and comprises six exons. The protein encoded by this gene is a beta chain of the major histocompatibility complex (MHC) class II molecules, which are expressed in antigen-presenting cells (APCs).

Function

The protein produced by the HLA-DQB2 gene plays a vital role in the immune system's defense against foreign substances. It does this by binding to peptides derived from these substances and presenting them on the cell surface for recognition by the appropriate T-cells. This process is crucial for the immune system's ability to fight off infections and diseases.

Clinical significance

Alterations in the HLA-DQB2 gene have been associated with various autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and celiac disease. Further research is needed to fully understand the role of HLA-DQB2 in these and other conditions.

See also

• Human leukocyte antigen
• Major histocompatibility complex
• Antigen-presenting cell
• T cell

References

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