HLA-DQB3

HLA-DQB3 is a gene that belongs to the HLA-DQ subregion of the human leukocyte antigen (HLA) complex. The HLA complex is a group of genes located on chromosome 6 that are essential for the immune system to recognize and respond to foreign substances. The HLA-DQB3 gene specifically encodes a protein that plays a crucial role in the immune response.

Function

The HLA-DQB3 gene encodes a protein that is part of the HLA-DQ molecule, a type of major histocompatibility complex (MHC) class II molecule. MHC class II molecules are found on the surface of certain immune cells, where they present foreign substances (antigens) to the immune system. This triggers an immune response, including the production of antibodies, which help to fight off infections.

Role in Disease

Variations in the HLA-DQB3 gene have been associated with a number of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and celiac disease. These diseases occur when the immune system mistakenly attacks the body's own tissues. It is thought that certain variations in the HLA-DQB3 gene may make the immune system more likely to mistake the body's own tissues for foreign substances, leading to an autoimmune response.

Research

Research into the HLA-DQB3 gene is ongoing, with scientists seeking to better understand its role in the immune response and in disease. This research may lead to new treatments for autoimmune diseases and other conditions related to the immune system.

See Also

• Human leukocyte antigen
• Major histocompatibility complex
• Autoimmune disease