HLA-DR52

HLA-DR52 is a human leukocyte antigen serotype within the broader HLA-DR serogroup. The HLA-DR52 serotype is determined by the HLA-DRB3 gene. HLA-DR52 is associated with several autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and Sjögren's syndrome.

Structure and Function

HLA-DR52 is a cell surface protein involved in the immune system's recognition of foreign substances. It is part of the major histocompatibility complex (MHC) class II, which presents peptides from outside the cell to T cells. This presentation triggers an immune response, protecting the body from infection.

Genetics

The HLA-DRB3 gene, which codes for HLA-DR52, is located on the short arm of chromosome 6 (6p21.3). It is one of several genes within the HLA complex that are involved in immune system function. Variations in the HLA-DRB3 gene can influence the risk of developing certain autoimmune diseases.

Clinical Significance

HLA-DR52 has been implicated in several autoimmune diseases. For example, it is more common in people with rheumatoid arthritis, systemic lupus erythematosus, and Sjögren's syndrome. However, the exact role of HLA-DR52 in these diseases is not fully understood and is the subject of ongoing research.

See Also

• Human leukocyte antigen
• Major histocompatibility complex
• Autoimmune disease
• Rheumatoid arthritis
• Systemic lupus erythematosus
• Sjögren's syndrome