HLA-DRB4

HLA-DRB4 is a gene that provides instructions for making a protein that plays a critical role in the immune system. The HLA-DRB4 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

Function

The HLA-DRB4 gene belongs to the HLA class II, DR beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

Clinical significance

HLA-DRB4 is associated with several autoimmune conditions, including rheumatoid arthritis, systemic lupus erythematosus, and pemphigus vulgaris. It is also associated with susceptibility to infectious diseases such as tuberculosis and hepatitis B.

Genetics

The HLA-DRB4 gene is located on the short (p) arm of chromosome 6 at position 21. The gene is part of the HLA complex, which is located on chromosome 6p21.3.

See also

• Human leukocyte antigen
• HLA-DR

External links

• HLA-DRB4 at the National Center for Biotechnology Information

HLA-DRB4 Resources
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