HLF (gene)

HLF (gene) is a gene that encodes the hepatic leukemia factor (HLF) in humans. This gene is located on the short arm of chromosome 17 (17p13.1). The HLF protein is a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors.

Function

The HLF gene is involved in the regulation of circadian rhythms. It is a transcription factor that forms a heterodimer with other bZIP proteins and binds to the CRE in the promoter of various genes. The protein is also involved in the regulation of gene expression in specific tissues, including the liver and hematopoietic cells.

Clinical significance

Mutations in the HLF gene have been associated with a rare form of leukemia known as Hepatic Leukemia. This is a type of leukemia that primarily affects the liver. The HLF gene has also been implicated in other types of cancers, including breast cancer and colorectal cancer.

Structure

The HLF protein is composed of 295 amino acids and has a molecular weight of approximately 33 kDa. It contains a basic region for DNA binding, a leucine zipper for dimerization, and a proline and acidic-rich region.

See also

• bZIP transcription factor
• Leukemia
• Gene expression
• Circadian rhythm

References

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