HMR 1883

HMR 1883 is a pharmacological agent that belongs to the class of statins, which are drugs primarily used to lower lipid levels in the blood. It is a synthetic lipid-lowering agent that inhibits HMG-CoA reductase, an enzyme that plays a central role in the production of cholesterol in the liver.

Mechanism of Action

HMR 1883, like other statins, works by inhibiting the enzyme HMG-CoA reductase. This enzyme is responsible for the conversion of HMG-CoA to mevalonate, a necessary step in the biosynthesis of cholesterol. By inhibiting this enzyme, HMR 1883 reduces the amount of cholesterol produced in the liver, leading to a decrease in total cholesterol levels in the blood.

Pharmacokinetics

After oral administration, HMR 1883 is rapidly absorbed from the gastrointestinal tract. It undergoes extensive first-pass metabolism in the liver, the primary site of action, before it is excreted in the bile. The elimination half-life of HMR 1883 is approximately 2 to 3 hours.

Clinical Use

HMR 1883 is used in the treatment of hypercholesterolemia, a condition characterized by high levels of cholesterol in the blood. It is also used in the prevention of cardiovascular disease, as high cholesterol levels are a risk factor for the development of atherosclerosis and coronary artery disease.

Side Effects

The most common side effects of HMR 1883 include gastrointestinal symptoms such as nausea, diarrhea, and abdominal pain. Other side effects may include headache, dizziness, and rash. Rare but serious side effects include liver damage, muscle inflammation, and rhabdomyolysis.

See Also

• Statins
• HMG-CoA reductase
• Hypercholesterolemia
• Cardiovascular disease