HOXA4
HOXA4 is a gene that belongs to the homeobox family of genes. The HOX genes are a group of related genes that control the body plan of an embryo along the head-tail axis. After the embryo is formed, HOX genes help with the formation of structures and organs.
Function[edit | edit source]
The HOXA4 gene provides instructions for making a protein that plays a crucial role in development before birth. This protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. Researchers believe that the HOXA4 protein controls the formation of certain parts of the upper body, including the second and third neck vertebrae (the bones that form the spinal column).
Clinical Significance[edit | edit source]
Mutations in the HOXA4 gene have been associated with various medical conditions. For instance, a mutation in this gene can lead to congenital heart defects, vertebral anomalies, and esophageal atresia. However, more research is needed to fully understand the role of the HOXA4 gene in human health and disease.
See Also[edit | edit source]
- Homeobox
- HOX genes
- Transcription factor
- Congenital heart defects
- Vertebral anomalies
- Esophageal atresia
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
