HOXC8

HOXC8 is a gene that in humans is encoded by the HOXC8 genetic sequence. This gene is a member of the Homeobox gene family, which are critical in the regulation of body plan development. The HOXC8 gene is specifically part of the Hox gene cluster on chromosome 12.

Function

The HOXC8 gene is involved in the regulation of cell differentiation and morphogenesis during embryonic development. It is expressed in a variety of tissues, including the spinal cord, skeletal muscle, and heart. The protein encoded by this gene is a transcription factor that can bind to DNA and regulate the expression of other genes.

Clinical Significance

Mutations in the HOXC8 gene have been associated with several medical conditions. For example, it has been linked to congenital heart defects, skeletal dysplasia, and certain types of cancer. In cancer, HOXC8 is often overexpressed, leading to abnormal cell growth and proliferation.

Research

Research into the HOXC8 gene is ongoing, with scientists seeking to better understand its role in development and disease. This includes studying its function in normal development, as well as how mutations in the gene can lead to disease.

See Also

• Homeobox
• Hox gene
• Chromosome 12

References

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