HOXD8

HOXD8 is a gene that encodes a protein belonging to the homeobox family of transcription factors. These proteins play a crucial role in the regulation of developmental processes and morphogenesis in multicellular organisms.

Function

The HOXD8 gene is part of the HOXD gene cluster, which is located on chromosome 2. This cluster is one of four similar clusters found in the human genome, the others being HOXA, HOXB, and HOXC. The proteins encoded by these genes are involved in the patterning of the anterior-posterior axis during embryonic development.

HOXD8, like other homeobox genes, contains a homeodomain, which is a DNA-binding domain that allows the protein to bind to specific DNA sequences and regulate the expression of target genes. This regulation is essential for the proper development of limbs, vertebrae, and other body structures.

Clinical significance

Mutations or dysregulation of HOXD8 and other homeobox genes can lead to developmental disorders and have been implicated in certain types of cancer. Research is ongoing to better understand the specific roles of HOXD8 in these processes and its potential as a target for therapeutic intervention.

See also

• Homeobox
• Transcription factor
• Gene expression
• Developmental biology

External links

• HOXD8 gene - NCBI
• HOXD8 - Genetics Home Reference