HS6ST2
HS6ST2 is a gene that encodes the enzyme heparan sulfate 6-O-sulfotransferase 2 in humans. This enzyme is involved in the modification of heparan sulfate, a type of glycosaminoglycan that plays a crucial role in cell-cell communication and interactions with the extracellular matrix.
Function[edit | edit source]
The HS6ST2 gene is responsible for the production of heparan sulfate 6-O-sulfotransferase 2. This enzyme catalyzes the transfer of sulfate groups to the 6-O position of glucosamine residues in heparan sulfate. This modification is important for the function of heparan sulfate, as it influences its ability to bind to various growth factors, chemokines, and morphogens.
Clinical Significance[edit | edit source]
Mutations in the HS6ST2 gene have been associated with several medical conditions. For example, research has suggested a link between HS6ST2 and hypertension, with certain variants of the gene potentially increasing the risk of developing this condition. Additionally, the gene has been implicated in the development of certain types of cancer, including breast cancer and colorectal cancer.
See Also[edit | edit source]
References[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
