TAAR1
(Redirected from HTAAR1)
TAAR1 (Trace Amine-Associated Receptor 1) is a protein that in humans is encoded by the TAAR1 gene. TAAR1 is a high-affinity receptor for trace amines, a class of amines that are found in low levels in mammalian systems, but have significant physiological effects.
Function[edit | edit source]
TAAR1 is a G protein-coupled receptor (GPCR) that is expressed in the brain and peripheral tissues of humans and other mammals. It is thought to play a role in the regulation of neurotransmitter systems, including dopamine, serotonin, and norepinephrine. TAAR1 activation has been shown to reduce the activity of these neurotransmitter systems, suggesting a potential role in the treatment of psychiatric disorders such as schizophrenia, depression, and substance abuse.
Clinical significance[edit | edit source]
Several studies have suggested that TAAR1 may be a promising target for the treatment of a variety of psychiatric disorders. For example, TAAR1 agonists have been shown to have antipsychotic effects in animal models of schizophrenia, and to reduce drug-seeking behavior in models of addiction. In addition, TAAR1 antagonists have been shown to have antidepressant effects in animal models of depression.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- TAAR1 at WikiMD
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