Halasartan
Antihypertensive medication
Halasartan is a medication used primarily for the treatment of hypertension (high blood pressure). It belongs to a class of drugs known as angiotensin II receptor antagonists, which work by blocking the effects of angiotensin II, a hormone that causes blood vessels to constrict. By inhibiting this hormone, Halasartan helps to relax blood vessels, thereby lowering blood pressure and improving blood flow.
Mechanism of Action[edit | edit source]
Halasartan functions by selectively blocking the binding of angiotensin II to the angiotensin II receptor type 1 (AT1 receptor) in various tissues, including vascular smooth muscle and the adrenal gland. This blockade prevents the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation and a reduction in blood pressure.
Pharmacokinetics[edit | edit source]
Halasartan is administered orally and is well absorbed from the gastrointestinal tract. It undergoes minimal hepatic metabolism and is primarily excreted unchanged in the urine. The drug has a half-life of approximately 24 hours, allowing for once-daily dosing.
Clinical Use[edit | edit source]
Halasartan is indicated for the management of hypertension, either as monotherapy or in combination with other antihypertensive agents. It may also be used in the treatment of heart failure and for renal protection in patients with diabetes mellitus and chronic kidney disease.
Side Effects[edit | edit source]
Common side effects of Halasartan include dizziness, headache, and fatigue. Less commonly, it may cause hyperkalemia, renal impairment, or allergic reactions. Patients are advised to monitor their blood pressure regularly and report any unusual symptoms to their healthcare provider.
Contraindications[edit | edit source]
Halasartan is contraindicated in patients with known hypersensitivity to the drug or any of its components. It should not be used during pregnancy due to the risk of fetal harm. Caution is advised in patients with renal artery stenosis or severe renal impairment.
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