Halogenated hydrocarbon

Halofantrine Hydrochloride is a drug used in the treatment of malaria. It is a phenanthrene methanol derivative, belonging to the class of antimalarial drugs known as antimalarial phenanthrenes. Halofantrine Hydrochloride is not a first-line treatment for malaria, but is used when other treatments have failed or are not available.

Pharmacology

Halofantrine Hydrochloride works by inhibiting the growth of parasites in the red blood cells of the human body. It interferes with the digestion of hemoglobin by the parasites, which is a crucial process for their survival. The exact mechanism of action of Halofantrine Hydrochloride is not fully understood, but it is believed to involve the inhibition of DNA synthesis in the parasites.

Usage

Halofantrine Hydrochloride is used in the treatment of both Plasmodium falciparum and Plasmodium vivax malaria. It is not used as a first-line treatment due to its potential for serious cardiac side effects, including QT interval prolongation and ventricular arrhythmias. It is typically used when other treatments have failed or are not available.

Side Effects

Common side effects of Halofantrine Hydrochloride include nausea, vomiting, abdominal pain, and diarrhea. More serious side effects can include cardiac arrhythmias, QT interval prolongation, and in rare cases, cardiac arrest.

Precautions

Halofantrine Hydrochloride should not be used in patients with known cardiac disease, or in those taking other medications known to prolong the QT interval. It should also be used with caution in patients with liver disease or kidney disease, as these conditions can affect the metabolism and excretion of the drug.

See Also

• Antimalarial medication
• Malaria
• Plasmodium falciparum
• Plasmodium vivax