Hematoporphyrin

Hematoporphyrin is a type of porphyrin that is involved in the formation of heme, a component of hemoglobin. Hematoporphyrin is a complex organic compound that contains four pyrrole rings linked by methine bridges. It is an important intermediate in the biosynthesis of heme, the prosthetic group of hemoglobin, myoglobin, and cytochrome.

Structure and Properties

Hematoporphyrin has a complex structure consisting of four pyrrole rings linked by methine bridges. Each pyrrole ring contains a nitrogen atom, which can coordinate with a metal ion to form a metalloporphyrin. In the case of heme, the metal ion is iron.

Biosynthesis

The biosynthesis of hematoporphyrin involves several steps. The first step is the formation of aminolevulinic acid (ALA) from glycine and succinyl-CoA. This reaction is catalyzed by the enzyme ALA synthase. ALA is then converted to porphobilinogen, which is subsequently polymerized to form a linear tetrapyrrole. This tetrapyrrole is then cyclized and oxidized to form uroporphyrinogen III, which is further converted to coproporphyrinogen III. The final steps involve the decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, which is then oxidized to form protoporphyrin IX. The insertion of iron into protoporphyrin IX results in the formation of heme.

Clinical Significance

Abnormalities in the biosynthesis of hematoporphyrin can lead to a group of disorders known as porphyrias. These disorders are characterized by the accumulation of porphyrins or porphyrin precursors in the body, which can lead to a variety of symptoms including skin sensitivity to sunlight, abdominal pain, and neurological complications.

See Also

• Heme
• Hemoglobin
• Porphyrin
• Porphyrias

Hematoporphyrin Resources
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