High-dose chemotherapy and bone marrow transplant

High-dose Chemotherapy and Bone Marrow Transplant

High-dose chemotherapy and bone marrow transplant (BMT) is a medical procedure used primarily to treat certain types of cancer, such as leukemia, lymphoma, and multiple myeloma. This treatment involves administering high doses of chemotherapy to eradicate cancer cells, followed by the infusion of healthy bone marrow stem cells to restore the bone marrow's ability to produce blood cells.

Overview

High-dose chemotherapy is a treatment regimen that uses higher than normal doses of chemotherapy drugs to kill cancer cells. While effective at destroying cancer cells, these high doses also damage the bone marrow, which is responsible for producing blood cells. To counteract this effect, a bone marrow transplant is performed to replenish the bone marrow with healthy stem cells.

Types of Bone Marrow Transplant

There are two main types of bone marrow transplants:

• Autologous Transplant: In this procedure, the patient's own stem cells are collected before chemotherapy and then re-infused after treatment. This type is often used when the risk of cancer cells in the bone marrow is low.

• Allogeneic Transplant: This involves using stem cells from a donor. The donor's cells must be a close match to the patient's tissue type to reduce the risk of complications. Allogeneic transplants are used when the patient's bone marrow is affected by cancer or when a genetic match is available.

Procedure

The process of high-dose chemotherapy and bone marrow transplant involves several steps:

1.Collection of Stem Cells: For autologous transplants, stem cells are collected from the patient's blood or bone marrow. For allogeneic transplants, stem cells are collected from a donor.

2.High-dose Chemotherapy: The patient receives high doses of chemotherapy drugs to destroy cancer cells. This phase may also include radiation therapy.

3.Infusion of Stem Cells: After chemotherapy, the collected stem cells are infused into the patient's bloodstream. These cells travel to the bone marrow and begin to produce new blood cells.

4.Recovery: The patient is monitored closely for several weeks as the new bone marrow begins to function. During this time, the patient is at risk for infections and other complications due to a weakened immune system.

Risks and Complications

High-dose chemotherapy and bone marrow transplant can have significant risks, including:

• Infections: Due to the temporary loss of immune function, patients are highly susceptible to infections.
• Graft-versus-host disease (GVHD): In allogeneic transplants, the donor cells may attack the recipient's body.
• Organ Damage: High-dose chemotherapy can cause damage to organs such as the liver, kidneys, and heart.

Outcomes

The success of high-dose chemotherapy and bone marrow transplant varies depending on the type of cancer, the stage of the disease, and the patient's overall health. Advances in medical technology and supportive care have improved outcomes and reduced complications.

Also see

• Leukemia
• Lymphoma
• Multiple Myeloma
• Chemotherapy
• Stem Cell Transplantation

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on High-dose chemotherapy and bone marrow transplant for any updates.

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