Homologous chromosomes

From WikiMD's Wellness Encyclopedia

Homologous Chromosomes are a pair of chromosomes, one from each parent, that are similar in shape and size. They contain the same genes in the same location (locus) but may contain different alleles of the same gene.

Overview[edit | edit source]

Homologous chromosomes are crucial for the process of meiosis, which is the type of cell division responsible for sexual reproduction. During meiosis, homologous chromosomes pair up and exchange genetic material in a process known as crossing over. This leads to the production of gametes with unique combinations of alleles, contributing to genetic diversity.

Structure[edit | edit source]

Each homologous chromosome is made up of two chromatids connected by a centromere. The chromatids are identical copies of the chromosome produced during DNA replication. The centromere is a region of the chromosome that attaches to the spindle fibers during cell division.

Function[edit | edit source]

The main function of homologous chromosomes is to carry the same set of genes from both parents. These genes may have different versions, or alleles, which can lead to variations in traits. During meiosis, homologous chromosomes pair up and exchange genetic material in a process known as crossing over. This results in new combinations of alleles on each chromosome, which can lead to genetic diversity in offspring.

Role in Genetic Disorders[edit | edit source]

Errors in the separation of homologous chromosomes during meiosis can lead to genetic disorders. For example, Down syndrome is caused by an extra copy of chromosome 21, which occurs when the homologous chromosomes do not separate properly during meiosis.

See Also[edit | edit source]

Homologous chromosomes Resources
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Contributors: Prab R. Tumpati, MD