Hyaluronan-mediated motility receptor

Hyaluronan-mediated motility receptor (HMMR), also known as RHAMM (Receptor for Hyaluronan Mediated Motility), is a protein that in humans is encoded by the HMMR gene. This protein is involved in cell motility, and is implicated in various processes such as cell migration, proliferation, and differentiation.

Structure

The HMMR gene is located on the short (p) arm of chromosome 5 at position 33.2. The protein encoded by this gene is approximately 85 kDa in size and is composed of 777 amino acids. The protein has a central coiled-coil domain and two hyaluronan-binding motifs (HABMs) at the N- and C-termini.

Function

HMMR is a non-integral cell surface protein that is involved in cell motility. It interacts with hyaluronan, a major component of the extracellular matrix, and plays a crucial role in cell migration, proliferation, and differentiation. HMMR is also involved in the regulation of mitotic spindle assembly and chromosome segregation during cell division.

Clinical significance

Alterations in the expression of HMMR have been associated with various types of cancer, including breast, colorectal, and lung cancers. Overexpression of HMMR has been shown to promote tumor growth and metastasis. In addition, HMMR has been identified as a potential therapeutic target for cancer treatment.

See also

• Hyaluronan
• Cell motility
• Extracellular matrix
• Mitotic spindle
• Cell division

External links

• HMMR at the National Center for Biotechnology Information (NCBI)