Hydrocortisone aceponate

Hydrocortisone aceponate

Hydrocortisone aceponate is a corticosteroid that is used in the treatment of various dermatological conditions. It is a synthetic glucocorticoid that has anti-inflammatory, anti-pruritic, and vasoconstrictive properties.

Pharmacology

Hydrocortisone aceponate is a prodrug that is metabolized in the skin to hydrocortisone, a natural glucocorticoid. It exerts its effects by binding to the glucocorticoid receptor, which leads to changes in gene transcription and protein synthesis. This results in a decrease in the production of inflammatory mediators and a reduction in the immune response.

Clinical Use

Hydrocortisone aceponate is used topically to treat a variety of skin conditions, including eczema, psoriasis, and contact dermatitis. It is also used to treat insect bites and sunburn. The drug is typically applied to the affected area once or twice daily.

Side Effects

Like other corticosteroids, hydrocortisone aceponate can cause side effects. These may include skin thinning, skin atrophy, and telangiectasia. Long-term use can also lead to systemic side effects such as Cushing's syndrome and adrenal suppression.

Contraindications

Hydrocortisone aceponate should not be used in patients with known hypersensitivity to hydrocortisone or any of the other ingredients in the formulation. It is also contraindicated in patients with tuberculosis of the skin, chickenpox, herpes simplex, and vaccinia.

See Also

• Corticosteroid
• Glucocorticoid receptor
• Prodrug
• Eczema
• Psoriasis
• Contact dermatitis

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