IFI16

IFI16 is a protein that in humans is encoded by the IFI16 gene. It is a member of the HIN-200 family of proteins, which are characterized by the presence of two HIN domains and one PYRIN domain. IFI16 is involved in various cellular processes, including DNA damage response, apoptosis, and innate immunity.

Function

IFI16 is a nuclear protein that plays a role in the maintenance of chromatin structure and in the regulation of gene expression. It acts as a DNA sensor, detecting viral and bacterial DNA in the cytoplasm and initiating an immune response. IFI16 also plays a role in the induction of apoptosis in response to DNA damage.

Clinical significance

Alterations in the expression of IFI16 have been associated with several diseases. Overexpression of IFI16 has been observed in a variety of cancers, including breast cancer, ovarian cancer, and colorectal cancer. It has also been implicated in autoimmune diseases, such as systemic lupus erythematosus and psoriasis.

Research

Research into the role of IFI16 in disease is ongoing. Studies have suggested that IFI16 may be a potential therapeutic target in cancers and autoimmune diseases. Further research is needed to fully understand the function of IFI16 and its potential as a therapeutic target.

See also

• HIN-200 family
• PYRIN domain
• DNA damage
• Apoptosis
• Innate immunity