IFNAR2
Introduction[edit | edit source]
IFNAR2 (Interferon Alpha and Beta Receptor Subunit 2) is a protein that in humans is encoded by the IFNAR2 gene. It is a critical component of the interferon receptor complex, which plays a vital role in the immune response to viral infections and other immune challenges.
Structure[edit | edit source]
IFNAR2 is a transmembrane protein that is part of the type I interferon receptor complex. This complex is composed of two subunits: IFNAR1 and IFNAR2. The IFNAR2 subunit is responsible for binding to type I interferons, such as interferon alpha and interferon beta.
The IFNAR2 protein has several domains:
- An extracellular domain that binds to interferons.
- A transmembrane domain that anchors the protein in the cell membrane.
- An intracellular domain that interacts with signaling molecules.
Function[edit | edit source]
The primary function of IFNAR2 is to mediate the biological effects of type I interferons. Upon binding of interferons to IFNAR2, a conformational change occurs that allows the receptor to associate with the Janus kinase (JAK) family of tyrosine kinases. This association leads to the activation of the JAK-STAT signaling pathway, which is crucial for the transcription of interferon-stimulated genes (ISGs).
These ISGs are involved in:
- Antiviral defense
- Regulation of cell growth
- Modulation of the immune response
Clinical Significance[edit | edit source]
Mutations or dysregulation of IFNAR2 can lead to altered immune responses. For example, defects in IFNAR2 have been associated with increased susceptibility to viral infections and may play a role in autoimmune diseases.
IFNAR2 is also a target for therapeutic interventions. Drugs that modulate the activity of IFNAR2 are being investigated for the treatment of various conditions, including multiple sclerosis and certain types of cancer.
Research[edit | edit source]
Ongoing research is focused on understanding the detailed mechanisms of IFNAR2 signaling and its role in disease. Studies are also exploring the potential of IFNAR2 as a biomarker for disease prognosis and treatment response.
Also see[edit | edit source]
 | This article about a biochemical receptor is a stub. You can help WikiMD by expanding it. |
| IFNAR2 | |
|---|---|
| Identifiers | |
| Symbol | ? |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
