IL-1-alfa
IL-1 alpha (Interleukin-1 alpha) is a protein that in humans is encoded by the IL1A gene. IL-1 alpha is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
Function[edit | edit source]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor. Interleukin 1 is involved in the inflammatory response, cell proliferation, differentiation, and apoptosis.
Clinical significance[edit | edit source]
IL-1 alpha has been implicated in a variety of diseases including rheumatoid arthritis, Alzheimer's disease, and cancer. It is also involved in the immune response to infections.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
