IL-1-alfa

IL-1 alpha (Interleukin-1 alpha) is a protein that in humans is encoded by the IL1A gene. IL-1 alpha is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.

Function

The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor. Interleukin 1 is involved in the inflammatory response, cell proliferation, differentiation, and apoptosis.

Clinical significance

IL-1 alpha has been implicated in a variety of diseases including rheumatoid arthritis, Alzheimer's disease, and cancer. It is also involved in the immune response to infections.

See also

• Interleukin 1
• Interleukin 1 receptor
• Caspase 1
• Macrophage

External links

• UniProt: P01583

IL-1-alfa Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski