IL-13
IL-13 is a cytokine secreted by T cells and mast cells that is involved in several immune system responses, including allergy and asthma pathogenesis. IL-13 is known to induce the production of IgE antibodies, which play a crucial role in the allergic response.
Function[edit | edit source]
IL-13 is a key mediator of inflammation and tissue remodeling. It is involved in the pathogenesis of several diseases, including asthma, allergy, and autoimmune diseases. IL-13 acts by binding to its receptor, IL-13R, which is expressed on a variety of cells, including B cells, eosinophils, fibroblasts, and smooth muscle cells.
Role in Disease[edit | edit source]
IL-13 has been implicated in a number of diseases. In asthma, IL-13 is thought to contribute to airway hyperresponsiveness and mucus production. In allergy, IL-13 is involved in the production of IgE antibodies, which are responsible for the allergic response. In autoimmune diseases, IL-13 has been shown to promote the production of autoantibodies.
Therapeutic Potential[edit | edit source]
Given its role in disease, IL-13 is a potential target for therapeutic intervention. Several drugs that target IL-13 or its receptor are currently in development for the treatment of asthma and other diseases.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
