IL-1B
IL-1B is a protein that in humans is encoded by the IL1B gene. It is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
Function[edit | edit source]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
Clinical significance[edit | edit source]
The synthesis of IL-1B is induced by various inflammatory stimuli and is produced by a variety of cells. It is involved in several disease states including inflammatory bowel disease, rheumatoid arthritis, Alzheimer's disease, and cancer.
See also[edit | edit source]
- Interleukin 1
- Cytokine
- Macrophage
- Caspase 1
- Inflammatory bowel disease
- Rheumatoid arthritis
- Alzheimer's disease
- Cancer
References[edit | edit source]
External links[edit | edit source]
- IL-1B at WikiMD
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Contributors: Prab R. Tumpati, MD
