IL17F

IL17F is a member of the Interleukin-17 family of cytokines, which are signaling molecules that play a crucial role in the immune response. IL17F is produced by T cells and is involved in several immune processes, including the recruitment of neutrophils and the production of other cytokines.

Function

IL17F is primarily involved in the immune response to bacterial and fungal infections. It stimulates the production of other cytokines, such as IL-6, IL-8, and GM-CSF, as well as chemokines that recruit neutrophils to the site of infection. IL17F also promotes the expression of defensins, which are antimicrobial peptides.

Role in Disease

Alterations in the function of IL17F have been associated with several diseases. For example, mutations in the IL17F gene have been linked to susceptibility to chronic mucocutaneous candidiasis, a condition characterized by persistent and recurrent infections of the skin, nails, and mucous membranes. IL17F has also been implicated in the pathogenesis of several autoimmune diseases, including psoriasis, rheumatoid arthritis, and multiple sclerosis.

Therapeutic Potential

Given its role in immune responses and disease, IL17F is a potential target for therapeutic intervention. Several drugs that target IL17F or its receptor are currently in development or clinical trials for the treatment of autoimmune diseases and other conditions.

See Also

• Interleukin-17 family
• Cytokines
• T cells
• Neutrophils
• Defensins