IL1A

IL1A (Interleukin 1 Alpha) is a protein that in humans is encoded by the IL1A gene. It is part of the interleukin family, a group of cytokines that play a crucial role in the regulation of immune response and inflammation.

Function

IL1A is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.

Clinical Significance

The gene encoding IL1A is associated with a number of inflammatory diseases, including rheumatoid arthritis, psoriasis, and multiple sclerosis. It has been implicated in a variety of other diseases as well, such as cancer, cardiovascular disease, and Alzheimer's disease.

See Also

• Interleukin 1
• Cytokine
• Inflammation
• Immune response

References

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