IL3RA

Interleukin-3 receptor alpha chain (also known as IL3RA) is a protein that in humans is encoded by the IL3RA gene. It is a part of the interleukin receptor family and plays a crucial role in the immune system.

Structure

The IL3RA gene is located on the X chromosome and consists of 10 exons. The protein encoded by this gene is a subunit of the interleukin 3 receptor (IL3R). This receptor is composed of an alpha chain (this protein) and a beta chain, which are associated with the cytokine receptor common gamma chain.

Function

IL3RA is involved in the transmission of signals for cell growth and differentiation. It is a part of the immune response and is expressed on the surface of several immune cells, including basophils, eosinophils, and dendritic cells. The binding of interleukin-3 to the IL3RA initiates a cascade of signals that leads to cell proliferation and differentiation.

Clinical significance

Mutations in the IL3RA gene have been associated with various diseases. For example, a high expression of IL3RA has been found in patients with acute myeloid leukemia (AML). This overexpression is associated with a poor prognosis. In addition, mutations in this gene have been linked to X-linked severe combined immunodeficiency (XSCID).

See also

• Interleukin-3
• Interleukin receptor
• Acute myeloid leukemia
• X-linked severe combined immunodeficiency

References

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian