IPAB (drug)

Ibuprofen.svg

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for relieving pain, helping with fever, and reducing inflammation. It is available under various brand names, including Advil, Motrin, and Nurofen. Ibuprofen is widely used due to its effectiveness and relatively low risk of side effects when used appropriately.

Pharmacology

Ibuprofen works by inhibiting the production of prostaglandins, which are chemicals in the body that promote inflammation, pain, and fever. It achieves this by blocking the enzyme cyclooxygenase (COX), specifically COX-1 and COX-2. This inhibition reduces the synthesis of prostaglandins, thereby alleviating symptoms of pain and inflammation.

Medical Uses

Ibuprofen is used to treat a variety of conditions, including:

• Headache
• Toothache
• Menstrual cramps
• Muscle pain
• Arthritis
• Fever

Dosage and Administration

Ibuprofen is available in various forms, including tablets, capsules, suspensions, and topical gels. The typical oral dose for adults is 200-400 mg every 4 to 6 hours, not exceeding 1200 mg per day without medical supervision. For children, the dose is based on weight and age.

Side Effects

Common side effects of ibuprofen include:

• Gastrointestinal discomfort
• Nausea
• Dizziness
• Rash

Serious side effects can include:

• Gastrointestinal bleeding
• Kidney damage
• Increased risk of heart attack or stroke

Contraindications

Ibuprofen should not be used in individuals with:

• Peptic ulcer disease
• Severe heart failure
• Allergy to NSAIDs

Interactions

Ibuprofen can interact with other medications, such as:

• Aspirin
• Anticoagulants
• Antihypertensives

History

Ibuprofen was discovered in 1961 by Stewart Adams and his colleagues at Boots UK Limited. It was initially marketed as a prescription drug in 1969 and became available over-the-counter in the 1980s.

Also see

• Nonsteroidal anti-inflammatory drug
• Paracetamol
• Aspirin
• Pain management

External links

• Ibuprofen on Drugs.com
• Ibuprofen - Mayo Clinic