IRAK3
IRAK3 (Interleukin-1 receptor-associated kinase 3), also known as IRAK-M, is a protein that in humans is encoded by the IRAK3 gene. It is a member of the Interleukin-1 receptor-associated kinase protein family. These kinases are important mediators in the signal transduction of Toll-like receptor (TLRs) and Interleukin-1 receptor (IL1R) signaling pathways.
Function[edit | edit source]
IRAK3 is unique among the IRAK proteins, as it is an inhibitor of the Toll-like receptor signaling pathway, which is responsible for the innate immune response to microbial pathogens. It is thought to control inflammatory responses and prevent endotoxin tolerance.
Clinical significance[edit | edit source]
Mutations in the IRAK3 gene have been associated with susceptibility to asthma related traits type 6 (ASRT6). ASRT6 is a form of asthma that is triggered by substances such as pollen, dust mites, and animal dander.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- IRAK3 at the National Center for Biotechnology Information
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Contributors: Prab R. Tumpati, MD
