IRGM
IRGM (Immunity-related GTPase family M) is a protein that in humans is encoded by the IRGM gene. It is a member of the immunity-related GTPase family and plays a crucial role in the immune system's defense against intracellular pathogens.
Function[edit | edit source]
The IRGM gene is involved in autophagy, a process that destroys intracellular pathogens. It is activated by interferon-gamma and can induce autophagy in human cells infected with Mycobacterium tuberculosis and Listeria monocytogenes, among other pathogens.
Clinical significance[edit | edit source]
Variations in the IRGM gene have been associated with susceptibility to inflammatory bowel disease type 10 (IBD10). Specifically, the disease is linked to a certain single nucleotide polymorphism (SNP) in the IRGM gene.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
