ISCU

ISCU (Iron-sulfur cluster assembly enzyme) is a protein that in humans is encoded by the ISCU gene. This protein is located in the mitochondria, the energy-producing centers of cells, and is involved in the formation of iron-sulfur clusters. These clusters are necessary for the function of many cellular enzymes, which carry out a variety of tasks including the regulation of DNA repair, protein synthesis, and energy production.

Function

The ISCU protein is a key component of the iron-sulfur cluster assembly machinery. Iron-sulfur clusters are necessary for the function of many cellular enzymes. The ISCU protein helps to assemble these clusters and then deliver them to the appropriate enzymes within the cell. This process is essential for the normal functioning of cells.

Clinical significance

Mutations in the ISCU gene can lead to a condition known as ISCU myopathy. This condition is characterized by muscle weakness and fatigue, as well as a variety of other symptoms. The condition is caused by a deficiency in the ISCU protein, which leads to a decrease in the function of iron-sulfur cluster-dependent enzymes.

See also

• Iron-sulfur proteins
• Mitochondria
• Myopathy

External links

• GeneCards - ISCU

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian