ITGA2B
ITGA2B (Integrin Subunit Alpha 2b) is a protein that in humans is encoded by the ITGA2B gene. This protein is a part of the integrin family and is primarily expressed on platelets. It plays a crucial role in the process of platelet aggregation and is a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin.
Function[edit | edit source]
ITGA2B, along with ITGB3, forms a heterodimer known as glycoprotein IIb/IIIa (GPIIb/IIIa). This complex is the most abundant integrin present on the surface of platelets. It is responsible for platelet aggregation by acting as a receptor for fibrinogen and von Willebrand factor, which are both involved in the blood clotting process.
Clinical Significance[edit | edit source]
Mutations in the ITGA2B gene can lead to conditions such as Glanzmann's thrombasthenia, a rare disorder characterized by the inability of platelets to properly aggregate and form clots. This can result in prolonged bleeding times and an increased risk of hemorrhage.
See Also[edit | edit source]
References[edit | edit source]
 | This protein-related article is a stub. You can help WikiMD by expanding it. |
 | This gene article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
