ITGA2B

ITGA2B (Integrin Subunit Alpha 2b) is a protein that in humans is encoded by the ITGA2B gene. This protein is a part of the integrin family and is primarily expressed on platelets. It plays a crucial role in the process of platelet aggregation and is a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin.

Function

ITGA2B, along with ITGB3, forms a heterodimer known as glycoprotein IIb/IIIa (GPIIb/IIIa). This complex is the most abundant integrin present on the surface of platelets. It is responsible for platelet aggregation by acting as a receptor for fibrinogen and von Willebrand factor, which are both involved in the blood clotting process.

Clinical Significance

Mutations in the ITGA2B gene can lead to conditions such as Glanzmann's thrombasthenia, a rare disorder characterized by the inability of platelets to properly aggregate and form clots. This can result in prolonged bleeding times and an increased risk of hemorrhage.

See Also

• Integrin
• Platelet
• Glanzmann's thrombasthenia