ITGA8

ITGA8 is a gene that encodes the integrin alpha 8 protein, which is a member of the integrin family. Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion. They are involved in various cellular processes, including cell signaling, cell migration, and cell differentiation.

Function

The integrin alpha 8 protein, encoded by the ITGA8 gene, forms a heterodimer with the beta 1 integrin subunit. This heterodimer is involved in the mediation of cell adhesion to the ECM. The ITGA8 protein plays a crucial role in the development of the kidney, lung, and nervous system. It is also implicated in the regulation of angiogenesis and tissue remodeling.

Clinical significance

Mutations or dysregulation of the ITGA8 gene have been associated with various diseases, including cancer and fibrosis. Research suggests that ITGA8 may play a role in tumor suppression and could be a potential target for cancer therapy.

Interactions

ITGA8 interacts with several proteins and molecules within the ECM, including fibronectin, tenascin, and vitronectin. These interactions are essential for the integrin's role in cell adhesion and signaling.

Research

Studies on ITGA8 have focused on its role in organ development and disease pathogenesis. Animal models have been used to investigate the function of ITGA8 in vivo, providing insights into its potential as a therapeutic target.

See also

• Integrin
• Cell adhesion
• Extracellular matrix

External links

• ITGA8 gene information at NCBI
• ITGA8 protein information at UniProt