ITGA8

ITGA8 or Integrin Subunit Alpha 8 is a protein that in humans is encoded by the ITGA8 gene. It is a member of the integrin family and has been implicated in various biological processes, including cell adhesion, cell-surface mediated signalling, and angiogenesis.

Structure[edit | edit source]

The ITGA8 protein is a type of integrin, a large family of proteins that are integral membrane proteins. They are composed of an alpha chain and a beta chain. The protein encoded by the ITGA8 gene is an alpha chain. It can pair with a beta 1 chain to form an integrin that interacts with extracellular matrix proteins and with several cellular proteins.

Function[edit | edit source]

ITGA8 plays a crucial role in the development and function of the kidney and cardiovascular system. It is involved in kidney morphogenesis and the regulation of kidney cell functions. In the cardiovascular system, ITGA8 is involved in the formation of blood vessels (angiogenesis) and the regulation of blood vessel tone.

Clinical significance[edit | edit source]

Mutations in the ITGA8 gene have been associated with several diseases, including renal agenesis, a condition in which one or both kidneys fail to develop. It has also been implicated in cancer progression and metastasis, particularly in breast cancer and lung cancer.

Research[edit | edit source]

Research is ongoing to further understand the role of ITGA8 in health and disease. This includes studies to identify potential therapeutic targets for diseases associated with ITGA8 dysfunction.

File:ITGA8 protein structure.jpg

Structure of the ITGA8 protein. Image from Wikimedia Commons.