ITGAV

ITGAV (Integrin Subunit Alpha V) is a protein that in humans is encoded by the ITGAV gene. It is a member of the integrin family and is recognized for its role in various biological processes, including cell adhesion, cell migration, and cell differentiation.

Function

ITGAV is a type of integrin that interacts with various extracellular matrix (ECM) proteins. It forms heterodimers with different beta subunits, which then interact with ECM proteins such as fibronectin, vitronectin, and collagen. This interaction is crucial for cell adhesion and migration, processes that are essential for wound healing and tissue regeneration.

Clinical Significance

Alterations in the ITGAV gene have been associated with several diseases. For instance, overexpression of ITGAV has been observed in various types of cancer, including breast cancer, lung cancer, and colorectal cancer. This overexpression is often correlated with poor prognosis. In addition, mutations in the ITGAV gene have been linked to glomerulonephritis, a type of kidney disease.

Research

Research on ITGAV is ongoing, with scientists exploring its role in disease progression and its potential as a therapeutic target. For example, drugs that inhibit ITGAV are currently being tested for their efficacy in treating various types of cancer.

File:ITGAV protein structure.jpg

The structure of the ITGAV protein. Image from Wikimedia Commons.

See Also

• Integrin
• Extracellular matrix
• Cell adhesion
• Cell migration