ITGB7

ITGB7 is a gene that encodes the integrin beta-7 protein in humans. This protein is a part of the integrin family, which are integral cell-surface proteins involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells.

Structure

The ITGB7 gene is located on the q arm of chromosome 12 at position 13.2. The gene spans approximately 59.5 kilobases and consists of 16 exons. The ITGB7 protein is a type I membrane protein that forms a heterodimeric complex with various alpha integrins.

Function

Integrin beta-7, the protein encoded by the ITGB7 gene, is involved in leukocyte adhesion and transmigration of leukocytes including T cells, B cells, dendritic cells, and macrophages. It is involved in immune response and plays a crucial role in the migration of leukocytes to inflammation sites.

Clinical Significance

Mutations in the ITGB7 gene have been associated with inflammatory bowel disease and other autoimmune diseases. The protein is also a potential target for the treatment of inflammatory diseases and certain types of cancer.

See Also

• Integrin
• Leukocyte
• Inflammatory bowel disease
• Autoimmune diseases

References

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