ITI-1549
A synthetic opioid analgesic
| ITI-1549 | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
ITI-1549 is a synthetic opioid analgesic that was developed for the treatment of moderate to severe pain. It is part of a class of drugs known as piperidine derivatives, which are characterized by their potent analgesic properties.
Chemical Structure[edit | edit source]
ITI-1549 is chemically classified as a piperidine derivative. Its IUPAC name is (3R,4R)-3-(Dimethylamino)-1-(2-phenylethyl)-4-(phenylthio)piperidine. The structure features a piperidine ring, which is a six-membered ring containing five carbon atoms and one nitrogen atom. The presence of a phenylthio group and a dimethylamino group contributes to its pharmacological activity.
Pharmacology[edit | edit source]
ITI-1549 acts primarily as an agonist at the mu-opioid receptor, which is responsible for its analgesic effects. Activation of this receptor leads to the inhibition of neurotransmitter release, resulting in decreased perception of pain. Like other opioids, ITI-1549 can produce side effects such as sedation, respiratory depression, and euphoria.
Clinical Use[edit | edit source]
ITI-1549 was developed for the management of moderate to severe pain, particularly in cases where other analgesics are ineffective. Its use is typically restricted to controlled clinical settings due to the potential for abuse and dependence associated with opioid medications.
Side Effects[edit | edit source]
Common side effects of ITI-1549 include nausea, vomiting, constipation, and drowsiness. More serious side effects can include respiratory depression, which can be life-threatening, especially in overdose situations. Long-term use can lead to tolerance and physical dependence.
Legal Status[edit | edit source]
The legal status of ITI-1549 varies by country, but it is generally classified as a controlled substance due to its potential for abuse and addiction. In many jurisdictions, it is available only by prescription and is subject to strict regulatory controls.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
