Imidacloprid/moxidectin

Imidacloprid/moxidectin is a combination of two active ingredients, imidacloprid and moxidectin, used in veterinary medicine. It is primarily used for the prevention and treatment of various types of parasites in animals.

Etymology

The term "imidacloprid" is derived from the chemical class of neonicotinoids, which are synthetic derivatives of nicotine. The term "moxidectin" is derived from the avermectin family of compounds, which are naturally occurring substances produced by the bacterium Streptomyces avermitilis.

Usage

Imidacloprid/moxidectin is used in the treatment and prevention of fleas, heartworm, ear mites, and some types of ticks and worms in animals. It is commonly used in dogs and cats, but can also be used in other animals under the guidance of a veterinarian.

Mechanism of Action

Imidacloprid works by binding to the nicotinic acetylcholine receptors in the nervous system of the parasite, causing paralysis and death. Moxidectin works by binding to the glutamate-gated chloride channels in the nervous system of the parasite, also causing paralysis and death.

Side Effects

Possible side effects of imidacloprid/moxidectin include vomiting, diarrhea, loss of appetite, lethargy, and skin reactions at the application site. In rare cases, neurological side effects such as tremors and seizures may occur.

Precautions

Imidacloprid/moxidectin should not be used in animals with a known hypersensitivity to either imidacloprid or moxidectin. It should also not be used in puppies or kittens less than 7 weeks of age.

See Also

• Neonicotinoids
• Avermectins
• Parasiticide