Indisetron

Indisetron is a potent, highly selective 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. It is a derivative of indazole and is structurally similar to other 5-HT3 receptor antagonists such as ondansetron and granisetron.

Pharmacology

Indisetron works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. It does this by binding to and blocking the 5-HT3 receptors located in the central nervous system and gastrointestinal tract, thereby preventing serotonin from activating these receptors.

Clinical Use

Indisetron is used primarily to control nausea and vomiting caused by chemotherapy. It is usually given before chemotherapy and may be continued for up to 24 hours afterwards. It can also be used to prevent nausea and vomiting after surgery.

Side Effects

Common side effects of indisetron include headache, dizziness, and constipation. Less common side effects may include arrhythmia, hypotension, and seizures. As with all medications, patients should be monitored for any adverse reactions.

Dosage

The dosage of indisetron varies depending on the individual and the condition being treated. It is usually given by injection into a vein shortly before chemotherapy is started.

See Also

• 5-HT3 receptor antagonist
• Chemotherapy-induced nausea and vomiting
• Ondansetron
• Granisetron