Inhibitory postsynaptic potential

Inhibitory Postsynaptic Potential

File:Inhibitory Postsynaptic Potential.png

A graphical representation of Inhibitory Postsynaptic Potential

The Inhibitory Postsynaptic Potential (IPSP) is a type of synaptic potential that decreases the likelihood of a neuron firing an action potential. This is achieved by hyperpolarizing the neuron's membrane potential, making it more negative and thus further from the threshold needed to trigger an action potential.

Mechanism

The IPSP is generated when a neurotransmitter binds to a specific receptor on the postsynaptic neuron. This binding opens ion channels that allow negatively charged ions to enter the neuron or positively charged ions to leave. This influx or efflux of ions makes the inside of the neuron more negative, thus hyperpolarizing the membrane potential.

Role in Neural Communication

IPSPs play a crucial role in the neural communication by providing a balance to the excitatory signals received by the neuron. Without IPSPs, the neuron would be in a constant state of excitation, which could lead to neuronal damage or neurological disorders.

See Also

• Excitatory postsynaptic potential
• Neurotransmitter
• Neuron
• Synapse