Insulin Glargine
What Is Insulin Glargine[edit | edit source]
Insulin Glargine (LANTUS) is a long-acting human insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus.
What are the uses of this medicine?[edit | edit source]
- This medicine is FDA approved to treat adults and children with type 1 diabetes and adults with type 2 diabetes to improve and maintain glycemic control.
- Insulin glargine is a long-acting insulin injected once daily and provides a basal level of insulin throughout the day.
How does this medicine work?[edit | edit source]
- The primary activity of insulin, including insulin glargine, is regulation of glucose metabolism.
- Insulin glargine is a recombinant analog of human insulin that binds to insulin receptors (IR).
- Insulin glargine has an onset of action of 1.5 to 2 hours.
- It has a long duration of action up to 24 hours.
Who Should Not Use this medicine ?[edit | edit source]
- This medicine cannot be used in patients with a documented hypersensitivity to the drug or one of its components.
- It also should not be administered during a hypoglycemic episode.
Is this medicine FDA approved[edit | edit source]
- Insulin glargine was approved for medical use in the United States in 2000.
- In 2018, it was the 26th most commonly prescribed medication in the United States with more than 24 million prescriptions.
How should this medicine be used?[edit | edit source]
- Dosage based on metabolic needs, blood glucose monitoring, glycemic control, type of diabetes, and prior insulin use.
- Administer subcutaneously into the abdominal area, thigh, or deltoid once daily at any time of day, but at the same time every day.
- Its administration includes a diluent with a pH of 4.0 to maintain the solubility of the drug before use.
- Patients should rotate injection sites to avoid lipodystrophy; these include the top of the thighs, back of the upper arms, buttocks, or abdomen.
What are the dosage forms and brand names of this medicine?[edit | edit source]
This medicine is avialable in fallowing dosage forms:
- 10 mL multiple-dose vial (3)
- 3 mL single-patient-use SoloStar prefilled pen
Type 1 Diabetes
- The recommended starting dose of LANTUS in patients with type 1 diabetes should be approximately one-third of the total daily insulin requirements.
- Short-acting, premeal insulin should be used to satisfy the remainder of the daily insulin requirements.
Type 2 Diabetes
- The recommended starting dose of LANTUS in patients with type 2 diabetes who are not currently treated with insulin is 0.2 units/kg or up to 10 units once daily.
This medicine is available in following brand names:
- Basaglar®
- Lantus®
- Toujeo®
- Soliqua®( Insulin Glargine and Lixisenatide)
What side effects can this medication cause?[edit | edit source]
Common possible side effects of this medicine include:
- hypoglycemia
- allergic reactions
- injection site reactions
- lipodystrophy
- pruritus
- rash
- edema
- weight gain.
What special precautions should I follow?[edit | edit source]
- Never share a LANTUS SoloStar prefilled pen between patients, even if the needle is changed.
- Make changes to a patient's insulin regimen (e.g., insulin strength, manufacturer, type, injection site or method of administration) under close medical supervision with increased frequency of blood glucose monitoring.
- Increase frequency of glucose monitoring with changes to: insulin dosage, coadministered glucose lowering medications, meal pattern, physical activity; and in patients with renal or hepatic impairment and hypoglycemia unawareness.
- Instruct patients to check insulin labels before injection.
- Monitor potassium levels in patients at risk of hypokalemia and treat if indicated.
What to do in case of emergency/overdose?[edit | edit source]
- Excess insulin administration may cause hypoglycemia and hypokalemia.
- Mild episodes of hypoglycemia can usually be treated with oral carbohydrates.
- Adjustments in drug dosage, meal patterns, or exercise may be needed.
- More severe episodes of hypoglycemia with coma, seizure, or neurologic impairment may be treated with intramuscular/subcutaneous glucagon or concentrated intravenous glucose.
- After apparent clinical recovery from hypoglycemia, continued observation and additional carbohydrate intake may be necessary to avoid recurrence of hypoglycemia.
- Hypokalemia must be corrected appropriately.
Can this medicine be used in pregnency?[edit | edit source]
- Insulin glargine is not FDA-approved in pregnancy, although studies have not shown contraindications to its use or adverse fetal outcomes.
- It is considered a first-line treatment for gestational diabetes after lifestyle modifications have proven insufficient.
Can this medicine be used for Pediatrics?[edit | edit source]
- Safety and effectiveness of LANTUS have been established in the age group 6 to 15 years with type 1 diabetes.
What should I know about storage and disposal of this medication?[edit | edit source]
- LANTUS should not be stored in the freezer and should not be allowed to freeze.
- Discard LANTUS if it has been frozen.
- Protect LANTUS from direct heat and light.
- Store unopened insulin glargine vials and pens in the refrigerator.
- Unopened refrigerated insulin glargine can be stored until the date shown on the company's label.
- If a refrigerator is unavailable (for example, when on vacation), store the vials or pens at room temperature and away from direct sunlight and extreme heat.
- Unrefrigerated vials or pens can be used within 28 days; after that time they must be discarded.
- Opened vials can be stored for 28 days at room temperature or in the refrigerator.
- Opened pens must be stored at room temperature and may be used for up to 28 days after the first use.
- Dispose of any insulin that has been exposed to extreme heat or cold.
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