Interferon Lambda 4

Interferon Lambda 4 (IFNL4) is a type of interferon that is part of the interferon lambda family. It is a protein encoded by the IFNL4 gene in humans. This protein plays a crucial role in the immune response to viral infections, particularly hepatitis C.

Function

Interferon Lambda 4 is a cytokine, a type of protein that cells use to communicate with each other. It is involved in the immune response to viral infections. When a cell is infected with a virus, it produces interferons, which signal to other cells to increase their defenses. Interferon Lambda 4 is particularly important in the immune response to hepatitis C, a viral infection that affects the liver.

Structure

The IFNL4 gene is located on the long (q) arm of chromosome 19 at position 13.2. The protein encoded by this gene is a member of the interferon lambda family, which also includes interferon lambda 1, 2, and 3. These proteins are structurally similar to each other and to other types of interferons.

Clinical significance

Variations in the IFNL4 gene have been associated with the response to treatment for hepatitis C. Some variants are associated with a better response to treatment, while others are associated with a poorer response. This information can be used to guide treatment decisions for individuals with hepatitis C.

Research

Research is ongoing to better understand the role of Interferon Lambda 4 in the immune response and to develop new treatments for viral infections. This includes studies to understand how variations in the IFNL4 gene affect the response to treatment for hepatitis C and other viral infections.