Interleukin-1-alpha
Interleukin-1 alpha (IL-1α) is a protein that in humans is encoded by the IL1A gene. It is a part of the interleukin-1 family, a group of 11 cytokines, which plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.
Function[edit | edit source]
IL-1α is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
Clinical Significance[edit | edit source]
The aberrant production of IL-1α is associated with a variety of inflammatory diseases including rheumatoid arthritis, skin diseases, and cancer.
See Also[edit | edit source]
- Interleukin-1
- Interleukin-1 beta
- Interleukin-1 family
- Cytokines
- Macrophages
- Caspase 1
- Rheumatoid arthritis
- Skin diseases
- Cancer
References[edit | edit source]
External Links[edit | edit source]
- Interleukin-1 alpha at UniProt
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Contributors: Prab R. Tumpati, MD
